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KMID : 0848120130380040135
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International Journal of Oral Biology
2013 Volume.38 No. 4 p.135 ~ p.140
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High dose of QX-314 produces anti-nociceptive effect without capsaicin in rats with inflammatory TMJ pain
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Ahn Dong-Kuk
Yang Kui-Ye
Kim Min-Su
Kim Eun-Kyung
Kong Mi-Sun
Ahn Jong-Soo
Lee Jong-Hun
Ju Jin-Sook
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Abstract
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The present study investigated the effects of QX-314 oninflammatory pain of the temporomandibular joint (TMJ).Experiments were carried out on male Sprague-Dawley ratsweighing 220-280 g. Under anesthesia, the TMJ of eachanimal was injected with 50 μL of formalin (5%). Thenumber of noxious behavioral responses, including rubbingor scratching of the facial region including the TMJ area,was recorded over 9 sequential 5 min intervals for eachanimal. Although 2.5% QX-314 did not affectformalin-induced nociceptive behavior, administration of5% QX-314 with formalin significantly decreased thenumber of scratches produced by the formalin injection.Co-administration of capsaicin, a TRPV1 agonist, with2.5% QX-314 produced significant anti-nociceptive effectswhereas 2.5% QX-314 alone did not. However, theco-administration of capsaicin did not enhance theanti-nociceptive effects in the 5% QX-314-treated rats.Moreover, the co-administration of capsazepine, a TRPV1antagonist, did not attenuate anti-nociceptive effects in the5% QX-314-treated rats. These findings suggest thatTRPV1 is effective in the transport of low but not highdoses of QX-314. Moreover, a high dose of QX-314, whichis not mediated by peripheral TRPV1 activity, may beviable therapeutic strategy for inflammatory pain in theTMJ.
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KEYWORD
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QX-314, TMJ pain, Capsaicin, Capsazepine, formalin test
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